Splenomegaly and splenectomy in sarcoidosis.

Splenomegaly and splenectomy in sarcoidosis.

The natural history of 30 patients with sarcoidosis who showed histological evidence of granulomatous involvement of the spleen has been studied; 24 patients had splenomegaly, 16 of whom had splenectomy. The main indication for splenectomy was splenomegaly and resultant discomfort. Corticosteroids reduced spleen size but reduction or withdrawal of the relatively high dosage required resulted in...

Splenectomy in tropical splenomegaly.

"Big Spleen Disease"-Hamilton et al. MEBRITCLSH 825 44%. His only treatment has been a 15-day course of primaquine followed by 100 mg. of proguanil daily. This is further evidence for a malarial cause of this syndrome and also for implicating the spleen in the plasma volume changes. The role of the spleen is also shown by a case of Felty's syndrome (Pengelly, 1966), in which a marked reduction ...

Splenectomy for Tropical Splenomegaly

Splenectomy for Splenomegaly

Physician to the Bristol Royal Infirmary.

Splenectomy in patients with undiagnosed splenomegaly.

Of splenectomies performed in the Cork Regional Hospital over an 11 year period, ten were undertaken primarily for diagnostic purposes. A definitive histological diagnosis was established in nine patients, seven of whom had lymphoma, two with Hodgkin's disease and five with non-Hodgkin's lymphoma. The weight of the excised spleen in all patients with lymphoma exceeded 1 kg; in all those with a ...